SRGAP1 — SLIT-ROBO Rho GTPase activating protein 1
SRGAP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SRGAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Endothelial Activation Inflammation | LITAF, NAMPT, NFKB2, NUAK2, RELB, SBNO2, SELE, SLC35F2 +5 more | View in SCUBA |
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A +5 more | View in SCUBA |
| Fibroblasts | Interferon Response Inflammatory | A4GALT, ABCA1, ABHD17C, BASP1, CCL7, CLEC2B, IFI16, IFI6 +5 more | View in SCUBA |
| Macrophages | Transcriptional Kinase Regulation Housekeeping | BNC2, CABLES1, CACNB4, CDK8, ENOX2, FAF1, FOXO1, INPP4B +17 more | View in SCUBA |
| Monocytes | Tissue-Resident Macrophage Tissue adaptation | ALDH1A1, CPED1, DAAM2, EIF4B, FN1, H2AC19, HDAC9, IGHA2 +3 more | View in SCUBA |
About the gene
| Synonyms | ARHGAP13, KIAA1304 |
|---|---|
| Chromosome | 12: 63843761-64162217 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.