Actin Cytoskeleton
Gene co-expression module in Fibroblasts
| Category | Cytoskeletal |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes CFL1 (cofilin-1, actin filament severing/depolymerization), PFN1 (profilin-1, actin monomer binding/polymerization), CAPZA2 (F-actin barbed-end capping protein alpha-2), TUBB6 (beta-tubulin), ACTB (beta-actin), KIF5B (kinesin-1 heavy chain, microtubule motor) form a coherent actin/cytoskeletal polymerization program. RTN4 (reticulon-4, ER membrane shaping), PCBP1 (poly(rC)-binding protein), RBM3 (RNA binding, cold shock), SBDS (ribosome biogenesis), MORF4L2 (chromatin), VAPA (ER-membrane contact sites), CMTM6 (transmembrane), NDUFS5 (Complex I), COX8A (Complex IV) are peripheral. Moderate coherence reflects the mixed composition. Significantly upregulated in UC inflammation. Neighbor to M85 (WAVE-RAC1 actin), confirming cytoskeletal neighborhood.
Genes
ACTB, CAPZA2, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, NDUFS5, PCBP1, PFN1, RBM3, RTN4, SBDS, TUBB6, VAPA
Most correlated modules
- Actin-Integrin Adhesion · correlation 0.91
- Proteasome & OxPhos · correlation 0.90
- Mitochondrial Energy Metabolism · correlation 0.89
- Inflammatory Fibroblast Activation · correlation 0.88
- Mitochondrial OxPhos · correlation 0.88
- Focal Adhesion ECM · correlation 0.87
- Proteasome Biogenesis · correlation 0.87
- WAVE-RAC1 Actin · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.