ER Protein Folding
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
The top hub genes are CANX (calnexin), HSP90B1 (GRP94), PDIA3 (ERp57), TRAM1 (translocon-associated membrane protein), RPN2 (ribophorin II), TMED10 (p24 family cargo receptor), KDELR1 (ER retention receptor), and KTN1 (kinectin, ER membrane). These are canonical ER-resident chaperones, glycosylation machinery, and protein translocation components. TMBIM6 is an ER transmembrane protein regulating ER calcium and UPR. Together these genes define the ER protein folding and quality control machinery. The module is upregulated in UC/CD inflammation and reverses in remission, consistent with increased secretory demand on fibroblasts during inflammation. Neighbor modules M5 and M71 involve membrane/cytoskeletal programs, consistent with a shared secretory/membrane-trafficking neighborhood.
Genes
AHCYL1, CANX, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1, LAMTOR1, MTPN, PDIA3, PRKAR1A, RPN2, SET, TMBIM6, TMED10, TRAM1, UBXN4, XRN2
Most correlated modules
- ER-Golgi Trafficking · correlation 0.95
- ER-Golgi Trafficking · correlation 0.95
- ER Secretory Processing · correlation 0.93
- Proteasome & OxPhos · correlation 0.93
- General Housekeeping · correlation 0.92
- Mitochondrial Energy Metabolism · correlation 0.92
- WAVE-RAC1 Actin · correlation 0.92
- ER Protein Processing · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.