LAMA5 — Laminin subunit alpha 5
LAMA5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LAMA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more | View in SCUBA |
| Fibroblasts | Lamina Propria ECM ECM production | ADAMTS7, ADGRL4, ANGPTL6, BMP2, CBLN2, CYTL1, DHRS7C, FAM135B +14 more | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more | View in SCUBA |
About the gene
| Chromosome | 20: 62307955-62367312 |
|---|---|
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signaling and PTK2B/PYK2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.