TCR Vesicular Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | TCR Signaling |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 23 genes have a known function matching the annotation |
Why this annotation
The module contains CD3G and CD3D (TCR/CD3 complex signaling components), ZYX (zyxin, focal adhesion and immune synapse scaffold), MAP7D1 (microtubule-associated, T cell polarity), VAMP2 (SNARE protein, vesicle-plasma membrane fusion for secretory lysosome docking), LAMP1 (lysosomal membrane protein, cytotoxic granule marker), ARL8A (lysosome positioning along microtubules), WASHC3 (endosomal actin nucleation), CD99 (leukocyte diapedesis), ARRDC1 (arrestin-domain, receptor internalization/trafficking), YPEL3 (senescence-associated), ITM2B (membrane protein, lymphocyte activation). The combination of CD3D/CD3G (TCR complex) with VAMP2, LAMP1, ARL8A strongly suggests TCR-coupled vesicular/granule trafficking — the machinery linking TCR engagement to cytotoxic granule secretion or receptor internalization. ZYX and MAP7D1 support immune synapse formation.
Genes
ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3D, CD3G, CD99, FKBP8, HMG20B, ITM2B, LAMP1, MAP7D1, PLPBP, POLR3GL, RNF220, SSBP4, THAP11, TMEM203, VAMP2, WASHC3, YPEL3, ZYX
Most correlated modules
- T-bet Effector Differentiation · correlation 0.91
- NKG2D Cytotoxic Activation · correlation 0.89
- Lymphocyte Homeostatic Regulation · correlation 0.88
- Mitochondrial Biogenesis · correlation 0.83
- Basal Cell Maintenance · correlation 0.83
- ER-Lysosomal Trafficking · correlation 0.81
- ATP Synthase Complex · correlation 0.80
- T Cell Homeostasis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.