ZMIZ1 — Zinc finger MIZ-type containing 1
ZMIZ1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZMIZ1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Protein Biogenesis Protein processing & ER | AUP1, BAZ1B, DNAJC1, EMC10, EML3, FAM32A, FRG1, GLUD1 +10 more | |
| Macrophages | NF-κB AP-1 Signaling Inflammatory | ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more | View in SCUBA |
| Pericytes | TGF-β Cytoskeletal Remodeling Cytoskeletal | ARHGEF12, ASAP1, GRK5, LRRC32, MYH9, RAPGEF2, RFTN1, SERPINH1 +2 more | View in SCUBA |
| Smooth muscle cells | SMC focal adhesion Migration & adhesion | ANXA6, ARMCX6, C1orf21, CD99, DNAJC1, HSBP1, KANK1, MORF4L2 +7 more | View in SCUBA |
About the gene
| Synonyms | FLJ13541, hZIMP10, KIAA1224, MIZ, RAI17, RP11-519K18.1, Zimp10 |
|---|---|
| Chromosome | 10: 79068966-79316519 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Acts as a transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.