TOPORS — TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
TOPORS belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TOPORS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | CD200 immunoregulation Immune regulation | B3GNT2, CAV1, CD200, CD79A, CH25H, CHGB, DUOX1, ELF2 +23 more | View in SCUBA |
| Gamma-delta T cells | Wnt-STAT3 Signaling TCR Signaling | BTBD1, COPA, CTNNB1, DHX9, EZR, HECTD1, NUP153, PAFAH1B1 +5 more | |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
About the gene
| Synonyms | LUN, RP31, TP53BPL |
|---|---|
| Chromosome | 9: 32540544-32552586 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | DNA damage, Ubl conjugation pathway |
Function
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.