Chromatin Epigenetic Regulation
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include NUP98 (nuclear pore/transcription), PRDM2 (histone H3K9 methyltransferase), JMJD1C (histone H3K9 demethylase), PHF20 (histone H4K20me reader), ARID4B (chromatin remodeling), TSPYL2 (nucleosome assembly), ELL2 (RNA Pol II elongation factor), and TIPARP (PARP/ADP-ribosylation). The module represents a coherent program of chromatin modification and epigenetic transcriptional regulation in gd T cells.
Genes
ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C, JMY, NAA50, NUP98, PFKFB3, PHF20, PNPLA8, PPP1CB, PRDM2, PRKAR2A, RAB21, REL, RNF19A, SUCO, TIPARP, TSPYL2, WHRN, ZCCHC2, ZNF331
Most correlated modules
- TCR Threshold Regulation · correlation 0.93
- ER Stress Response · correlation 0.93
- Stress Negative Feedback · correlation 0.91
- Pre-mRNA Splicing · correlation 0.90
- Ubiquitin-p53 Regulation · correlation 0.89
- NF-κB Activation · correlation 0.88
- cAMP Lipid Signaling · correlation 0.88
- hnRNP Splicing Complex · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.