EZR — Ezrin

EZR belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EZR's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR signaling TCR/AP1/NFKb pathway	AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, FAM177A1, FTH1, GCSAM +19 more	View in SCUBA
CD8⁺ T cells	RNA Processing Mixed RNA processing & translation	AIP, CALM1, FUBP1, HNRNPA2B1, HNRNPH3, LCP1, LRRFIP1, MOB1A +8 more	View in SCUBA
Endothelial	NF-κB Oxidative Stress Stress	ACP1, ALDH7A1, ARHGDIB, CCDC85C, CDC25B, CDKN3, CMSS1, COPRS +13 more	View in SCUBA
Gamma-delta T cells	Wnt-STAT3 Signaling TCR Signaling	BTBD1, COPA, CTNNB1, DHX9, HECTD1, NUP153, PAFAH1B1, SPRTN +5 more
Goblet cells	Stress Survival Response Stress	EPHA2, ERRFI1, KLF6, LDLR, LMNA, MCL1, NEDD9, SQSTM1 +3 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, FOS, ICAM1 +26 more	View in SCUBA
Macrophages	NF-κB AP-1 Signaling Inflammatory	ABL2, AGAP3, ARL8B, ATP1B3, ATP6V1H, B4GALT1, C5AR2, CDKN1A +21 more	View in SCUBA
Mucosal-associated invariant T cell	Stress Granule Response Stress	BZW1, CRTC2, G3BP2, HERPUD2, HNRNPUL1, MAP3K8, MAPK1IP1L, RNF138 +3 more
Natural Killer cells	NK Cell Activation activation	AKAP9, AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, GNL3, PPP1CB +2 more	View in SCUBA

About the gene

Synonyms	VIL2
Chromosome	6: 158765741-158819368
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Biological process	Cell shape

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.