Mitoribosome Small Subunit
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 33 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 33 genes have a known function matching the annotation |
Why this annotation
Hub genes include PSMA5 (proteasome alpha subunit), MRPS18B, MRPS18C, MRPS34, MRPS16 (mitochondrial ribosome small subunit proteins), COA3 (cytochrome c oxidase assembly factor), MTRFR (mitochondrial translation release factor), SRP9 (signal recognition particle), GEMIN6 (Gem-associated/snRNP assembly), ACADM (medium-chain acyl-CoA dehydrogenase/fatty acid beta-oxidation), GALK1 (galactose kinase). The dominant theme is mitochondrial ribosome small subunit with accessory mitochondrial translation/assembly factors. GEMIN6, SRP9 and PRIM1 are RNA/DNA processing outliers. This is a tightly defined mitoribosome-small-subunit module within the broader mitochondrial housekeeping neighborhood.
Genes
ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6, ISCA2, LYPLA2, MED11, MRPL15, MRPL46, MRPS16, MRPS18B, MRPS18C, MRPS26, MRPS34, MTRFR, NDUFA8, NDUFB5, NT5C, NUDT5, ORMDL2, PRIM1, PSMA5, RER1, RNASEH2B, SNAPIN, SRP9, SUCLG1, TMEM141, TMEM60
Most correlated modules
- Mitochondrial Translation · correlation 0.93
- Complex I Assembly · correlation 0.89
- Mitochondrial Housekeeping · correlation 0.86
- Chaperone Protein Folding · correlation 0.85
- DNA Damage Repair · correlation 0.81
- Cellular Homeostasis · correlation 0.80
- Endosomal Vesicle Trafficking · correlation 0.80
- Mitochondrial Dynamics · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.