T Cell Homeostasis
Gene co-expression module in Gamma-delta T cells
| Category | Housekeeping |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 13 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include TBC1D10C (Rab GTPase activating protein), RGS19 (G-protein signaling regulator), MYL12A (myosin light chain), CSK (C-terminal Src kinase—negative regulator of TCR/Src signaling), ATP6V0E1 (vacuolar ATPase), CSTB (cystatin B, cysteine protease inhibitor), DAD1 (dolichyl-PP oligosaccharyltransferase/apoptosis suppressor), VKORC1 (vitamin K epoxide reductase), FERMT3 (integrin-mediated adhesion in hematopoietic cells), VAMP8 (SNARE/vesicle fusion), PDLIM2 (LIM domain, T-cell activation scaffold), TMBIM4 (anti-apoptotic), SDHD (Complex II mitochondrial), CALHM2 (calcium homeostasis), CNPY2 (TLR/ER chaperone). The combination of vesicle trafficking, Src kinase regulation (CSK), integrin/adhesion (FERMT3), and anti-apoptotic genes (DAD1, TMBIM4) in T cells suggests a module related to basal T-cell homeostasis and signaling competence. Core coherence and uniform expression point to constitutive housekeeping-level expression. Most consistent label is general housekeeping with T-cell homeostatic flavor.
Genes
ATP6V0E1, CALHM2, CNPY2, CSK, CSTB, DAD1, FERMT3, GTF2H5, MYL12A, PDLIM2, RGS19, SDHD, TBC1D10C, TEX264, TMBIM4, TMEM179B, TMEM250, TMEM35B, VAMP8, VKORC1
Most correlated modules
- NKG2D Cytotoxic Activation · correlation 0.88
- T Cell Survival · correlation 0.87
- Cytotoxic Effector Actin · correlation 0.87
- Lymphocyte Homeostatic Regulation · correlation 0.87
- General Housekeeping Mixed · correlation 0.85
- Mitochondrial Translation · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.83
- Effector Cell Migration · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.