PYCR2 — Pyrroline-5-carboxylate reductase 2
PYCR2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PYCR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, COX7A2L, DNAJC7, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36 +11 more | |
| Innate lymphoid cells | Cellular Metabolic Maintenance Metabolism | ADIPOR1, APH1A, ARF5, BCAP31, CLIC1, CSNK2B, CYB5R3, DHPS +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Metabolism & Redox Mitochondrial & OxPhos | ATP5PF, CHURC1, DAD1, DHRS7, EGLN2, HMOX2, ITM2B, MRPS21 +7 more | |
| Natural Killer cells | NK TGF-β Regulation Immune regulation | AOAH, CSK, GIMAP5, NCR1, PPP1R18, PTPN6, SASH3, TGFBR2 +1 more | View in SCUBA |
About the gene
| Synonyms | P5CR2 |
|---|---|
| Chromosome | 1: 225919877-225924340 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Amino-acid biosynthesis, Proline biosynthesis |
Function
Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5- carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.