TIMM8B — Translocase of inner mitochondrial membrane 8 homolog B
TIMM8B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TIMM8B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ACSL4, ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3 +17 more | View in SCUBA |
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, ATP6V1F, EIF3I, MRPS6, NDUFS7, PARK7, PRDX6, PSMD4 +3 more | View in SCUBA |
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC3, CLTB, COX6A1, COX7A2, COX7B, DAD1, ELOB, MYL12B +9 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, COX7A2L, DNAJC7, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36 +11 more | |
| Innate lymphoid cells | Mitochondrial OxPhos Biogenesis Mitochondrial & OxPhos | AP1S1, ATOX1, ATP5ME, ATP5MF, C1QBP, CNIH1, CYC1, ERH +22 more | View in SCUBA |
About the gene
| Synonyms | DDP2, FLJ21744, MGC102866, MGC117373, TIM8B |
|---|---|
| Chromosome | 11: 112084800-112086798 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chaperone |
| Biological process | Protein transport, Translocation, Transport |
Function
Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.