Stress Epigenetic Silencing
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub NEU1 (lysosomal sialidase, protein catabolism), ALKBH5 (m6A RNA demethylase, epitranscriptomic regulation), SIAH2 (E3 ubiquitin ligase targeting HIF-1α and stress proteins), MXD1 (MAD1, MYC antagonist upregulated under stress/hypoxia), RGS2 (GTPase-activating protein, stress-induced signaling dampener), YME1L1 (mitochondrial inner membrane AAA-protease, mitochondrial quality control), PHF1 (PRC2 associated, H3K27me3 reader, epigenetic silencing), OTUD4 (deubiquitinase), RHOB (stress-inducible Rho GTPase), ANKHD1 (scaffolding/Hippo pathway), TOMM20 (mitochondrial outer membrane import receptor), ZBTB10 (transcriptional repressor). The module converges on stress-induced epigenetic silencing and RNA modification (ALKBH5, PHF1), with SIAH2/MXD1/RGS2 suggesting a hypoxia/stress-response overlay. Neighbor M89 features FOXO3/SQSTM1 stress-autophagy, consistent with this stress-regulatory neighborhood.
Genes
ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, NEU1, OTUD4, PHF1, PNO1, RBM27, RGS2, RHOB, SIAH2, TMEM185B, TOMM20, YME1L1, ZBTB10
Most correlated modules
- Autophagy Stress Response · correlation 0.89
- Ubiquitin-p53 Regulation · correlation 0.89
- ER Proteotoxic Stress · correlation 0.88
- hnRNP Splicing Complex · correlation 0.86
- MAPK Kinase Signaling · correlation 0.85
- Pre-mRNA Splicing · correlation 0.84
- TCR Early Activation · correlation 0.81
- Chromatin Epigenetic Regulation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.