NDUFAF8 — NADH:ubiquinone oxidoreductase complex assembly factor 8
NDUFAF8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDUFAF8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos | ATIC, ATP5MC1, C1QBP, CCT7, DCTPP1, EBNA1BP2, EEF1E1, EIF5A +13 more | View in SCUBA |
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ANP32A, ATP5F1A, ATP5F1B, COX7A2, COX7B, GADD45GIP1, GNG5, MRPL21 +10 more | View in SCUBA |
| Gamma-delta T cells | RNA Processing RNA processing & translation | ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, BUD23, CIAO2B, E2F4, ELAVL1 +12 more | |
| Hematopoietic progenitor cells | RNA Processing Housekeeping Housekeeping | ATP5MC1, C1QBP, CDK4, DUT, FABP5, HSPE1, LSM5, NME1 +8 more | |
| Innate lymphoid cells | RNA Splicing Processing RNA processing & translation | ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, DYNLRB1, FKBP3 +16 more | View in SCUBA |
About the gene
| Synonyms | C17orf89 |
|---|---|
| Chromosome | 17: 81239305-81241310 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
Function
Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.