SCUBA

SLFN5 — Schlafen family member 5

SLFN5 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SLFN5's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsPost-transcriptional regulation
RNA processing
BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 moreView in SCUBA
EndothelialEndothelial Barrier Homeostasis
migration & adhesion
AFDN, CD2AP, CLEC3B, ENPP2, IFNGR1, IL6R, ITGB4, JAM2 +11 moreView in SCUBA
Gamma-delta T cellsInterferon Antiviral Response
Inflammation
ANKRD44, DDX17, DDX60L, IARS2, KIAA0319L, KRBOX5, LZIC, MIA2 +14 more
Innate lymphoid cellsNK Cytotoxic Regulation
Cytotoxicity
ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 moreView in SCUBA
MacrophagesAutophagy Lysosomal Regulation
Lysosomal & pahgocytosis
ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B +22 moreView in SCUBA
Mucosal-associated invariant T cellChromatin Epigenetic Regulation
DNA/chromatin regulation
ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more
Natural Killer cellsNK Homeostatic Survival
Immune regulation
ACAP1, ARHGAP30, CAPN12, FYB1, GIMAP6, GPR174, IRF2, STOM +1 moreView in SCUBA
PericytesG1 Cell Cycle Entry
Cell cycle
CCND3, CCNY, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, MGAT1 +6 moreView in SCUBA

About the gene

SynonymsMGC19764
Chromosome17: 35243071-35273655
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins
Biological processDifferentiation

Function

May have a role in hematopoietic cell differentiation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.