ER-Lysosomal Trafficking
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 21 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 21 genes have a known function matching the annotation |
Why this annotation
TMCO1 maintains ER calcium homeostasis. ARL6IP5 localizes to ER/Golgi membranes. ATF6B is a UPR/ER stress transcription factor. SLC66A3 is a lysosomal transporter. CLN3 is a lysosomal membrane protein. SNX1 mediates endosomal cargo sorting. MGAT1 performs Golgi N-glycosylation. TXNDC12 is an ER oxidoreductase. This module reflects ER, Golgi, and lysosomal vesicular trafficking and protein processing. Moderate coherence with some peripheral members (UNC13D, PNPLA6) reflects overlap with degranulation machinery.
Genes
ARL6IP5, ATF6B, BORCS6, CD53, CLN3, DHRS7, MGAT1, MMP23B, NAA40, NPTN, PLAAT4, PNPLA6, PRR13, RTF2, SDAD1, SLC38A10, SLC66A3, SNX1, TMCO1, TXNDC12, UNC13D
Most correlated modules
- Lymphocyte Homeostatic Regulation · correlation 0.90
- Chromatin Epigenetic Regulation · correlation 0.86
- Actin Remodeling · correlation 0.84
- TGF-beta Signaling · correlation 0.83
- TCR Vesicular Trafficking · correlation 0.81
- SR Kinase & RNA · correlation 0.81
- T Cell Homeostasis · correlation 0.79
- Effector Cell Migration · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.