Effector IFN Response
Gene co-expression module in Gamma-delta T cells
| Category | cytotoxicity |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
This is a high-expression (mean 1.829), broadly detected (75.9%) module. Hub genes EMP3, S100A6, S100A4 (calcium-binding proteins upregulated in activated/migratory cells), B2M (MHC-I beta chain, universally expressed), TMSB10 (actin-sequestering thymosin, highly expressed in lymphocytes), FXYD5 (dysadherin, promotes migration), GZMM (granzyme M, cytotoxic effector), CYBA (NADPH oxidase subunit), IFITM1/IFITM2 (interferon-induced antiviral), ANXA1 (annexin A1, membrane repair and anti-inflammatory), LIME1 (LAT-interacting adaptor). The combination of S100A4/S100A6, FXYD5, and GZMM with IFITM1/2 suggests effector γδ T cells with interferon-stimulated and cytotoxic activity. The high mean expression and pct positive suggest this is a constitutive effector state module.
Genes
AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1, IFITM2, LIMD2, LIME1, PLAC8, S100A4, S100A6, S1PR4, SH3BGRL3, TMSB10, TSPO
Most correlated modules
- TCR Proximal Signaling · correlation 0.92
- Lymphocyte Tissue Egress · correlation 0.85
- Effector Cell Migration · correlation 0.84
- Coinhibitory Checkpoint · correlation 0.83
- Cytotoxic Effector Program · correlation 0.80
- T-bet Effector Differentiation · correlation 0.77
- γδ T Cell Identity · correlation 0.77
- Naive T cell quiescence · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.