ROMO1 — Reactive oxygen species modulator 1
ROMO1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ROMO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Proteostasis OxPhos Housekeeping | AIP, ARPC1B, ATP6V1F, C4orf48, CHMP2A, IL2RG, NDUFA13, NDUFB10 +6 more | View in SCUBA |
| CD8⁺ T cells | Proteasome Degradation Housekeeping | ARPP19, CLTA, GNG5, HSBP1, NDUFB4, POLR2J, POLR2K, PSMB2 +2 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial ETC Mitochondrial & OxPhos | COX7B, HMGB1, HMGN1, HMGXB4, LSM5, NDUFB6, PSMA6, RANGRF +5 more | |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Identity T cell maturation | ARPC1B, BLOC1S1, C4orf3, CD3D, CHKB, CPNE1, DDX39B, HMGN3 +9 more |
About the gene
| Synonyms | bA353C18.2, C20orf52, MTGMP |
|---|---|
| Chromosome | 20: 35699272-35700984 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Antibiotic, Antimicrobial |
Function
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.