LSM5 — LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
LSM5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LSM5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CDK4, CENPX, CYC1, FDPS, GGCT, LSM3 +14 more | View in SCUBA |
| CD4⁺ T cells | Ribosome biogenesis Housekeeping | APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA +17 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | ALYREF, BANF1, CNIH4, COX8A, HAUS1, HMGN1, ILF2, MRPL51 +8 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial ETC Mitochondrial & OxPhos | COX7B, HMGB1, HMGN1, HMGXB4, NDUFB6, PSMA6, RANGRF, RBM17 +5 more | |
| Goblet cells | S/G2 Preparation Cell cycle | DTYMK, EXOSC8, HMGN2, LMNB1, LSM3, MIS18A, MIS18BP1, SMC2 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | RNA Processing Housekeeping Housekeeping | ATP5MC1, C1QBP, CDK4, DUT, FABP5, HSPE1, NDUFAF8, NME1 +8 more | |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
About the gene
| Synonyms | YER146W |
|---|---|
| Chromosome | 7: 32485338-32495283 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.