ER Glycoprotein Quality Control
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 18 genes have a known function matching the annotation |
Why this annotation
Core hub genes RPN1 (ribophorin I, OST complex), STT3A (OST catalytic subunit), CALR (calreticulin ER chaperone), PDIA3 (ERp57, PDI family), HSP90B1 (GRP94), OS9 (ERAD lectin), PDIA4 form a tight N-glycosylation and ER protein quality control/ERAD program. GBP1, GBP2, GBP4 (guanylate-binding proteins, ISGs) and SLAMF7 are associated but appear to be peripheral additions reflecting IFN-stimulated co-expression. The dominant program is ER glycoprotein folding and quality control, consistent with neighbor M98.
Genes
APOL2, BAG6, CALR, ELP3, GBP1, GBP2, GBP4, HEXB, HSP90B1, NRBP1, OS9, PDIA3, PDIA4, PSMD6, RPN1, SLAMF7, STT3A, YARS1
Most correlated modules
- Antiviral ISG Response · correlation 0.85
- Butyrophilin gd Activation · correlation 0.82
- TCR Activation Signaling · correlation 0.81
- Interferon Stimulated Genes · correlation 0.78
- Vesicular Trafficking · correlation 0.77
- ER Antigen Processing · correlation 0.76
- Immune Synapse Cytoskeleton · correlation 0.74
- TGF-beta Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.