hnRNP Splicing Complex
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub SFPQ (splicing factor proline/glutamine-rich, also transcription repressor) is a canonical RNA-binding protein. HNRNPA1, HNRNPC, HNRNPH3 are core heterogeneous nuclear ribonucleoproteins essential for pre-mRNA splicing and export. PAPOLA (canonical poly-A polymerase), PABPC1 (cytoplasmic poly-A binding protein, translation), NOP58 (box C/D snoRNP, rRNA processing), DDX21 (DEAD-box helicase, ribosome biogenesis/splicing). PPP2CA (PP2A catalytic subunit), UBE2D3 (E2 ubiquitin), RNF114 (E3 ligase). This is a tightly co-expressed hnRNP/splicing module with additional RNA biogenesis components. Module M93 is a direct neighbor also enriched for splicing factors, confirming RNA processing neighborhood.
Genes
ASXL1, DDX21, HNRNPA1, HNRNPC, HNRNPH3, HSPA9, NOP58, PABPC1, PAPOLA, PPP2CA, RNF114, SFPQ, TOP1, UBE2D3
Most correlated modules
- Pre-mRNA Splicing · correlation 0.92
- Ubiquitin-p53 Regulation · correlation 0.91
- Autophagy Stress Response · correlation 0.89
- ER Proteotoxic Stress · correlation 0.88
- Chromatin Epigenetic Regulation · correlation 0.88
- DNA Damage Ubiquitin · correlation 0.86
- Stress Epigenetic Silencing · correlation 0.86
- MAPK Kinase Signaling · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.