RNF114 — Ring finger protein 114
RNF114 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF114's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | hnRNP Splicing Complex RNA processing & translation | ASXL1, DDX21, HNRNPA1, HNRNPC, HNRNPH3, HSPA9, NOP58, PABPC1 +5 more | |
| Lymphatic endothelial | NF-κB Autophagy Regulation Immune regulation | CLIC2, GABARAPL1, LGMN, NFKBIB, OSER1, PRRG4, RELB, SQSTM1 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more |
About the gene
| Synonyms | PSORS12, ZNF313 |
|---|---|
| Chromosome | 20: 49936336-49953885 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Developmental protein, Transferase |
| Biological process | Differentiation, Spermatogenesis, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Also acts as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.