Ubiquitin-p53 Regulation
Gene co-expression module in Gamma-delta T cells
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes RBBP6 (E3 ubiquitin ligase/p53 pathway), TP53BP2 (p53 binding), USP7 (deubiquitinase stabilizing p53/MDM2), TRIM39 and RNF139 (ubiquitin E3 ligases) form a clear ubiquitin-proteasome/p53 regulatory axis. YTHDC1 (m6A reader), CCNL1 (splicing-associated cyclin), and ATXN7 (SAGA deubiquitinase complex) add RNA processing and chromatin ubiquitination. HERPUD2 links to UPR-associated proteostasis. The module is coherent around ubiquitin-mediated protein regulation and p53 pathway control. Neighbor M97 also features ubiquitin ligases (RNF168, UBE2K) supporting this proteostatic neighborhood theme.
Genes
ATXN7, CCNL1, DCTN4, FNBP1, HERPUD2, MOB4, RBBP6, RNF139, TP53BP2, TRIM39, USP7, WDR26, YTHDC1
Most correlated modules
- Pre-mRNA Splicing · correlation 0.94
- MAPK Kinase Signaling · correlation 0.92
- hnRNP Splicing Complex · correlation 0.91
- Autophagy Stress Response · correlation 0.90
- Chromatin Epigenetic Regulation · correlation 0.89
- ER Proteotoxic Stress · correlation 0.89
- Stress Epigenetic Silencing · correlation 0.89
- DNA Damage Ubiquitin · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.