ER Proteotoxic Stress
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes ODC1 (polyamine synthesis), PPP1R15A (GADD34, eIF2α phosphatase in integrated stress response), HSPA5 (BiP/GRP78, canonical ER stress chaperone), CYCS (cytochrome c, apoptosis/stress), FOSB (AP-1 IEG), SAT1 (polyamine catabolism), MCL1 (pro-survival under ER stress), and SRSF7/SRSF5 (alternative splicing under stress) collectively define an ER/proteotoxic stress response. PPP1R15A and HSPA5 are canonical UPR markers. ODC1 and SAT1 together reflect polyamine flux changes during stress. The module is core-coherent, supporting a tight single program. Neighbor M142 (IEG/NF-κB activation) and M157 (heat stress/DNAJB9) reinforce this as part of a stress-activation neighborhood.
Genes
ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB, HSPA5, IDI1, IDS, KLF6, MCL1, MYADM, ODC1, PPP1R15A, RNMT, SAT1, SRSF5, SRSF7, YPEL5, ZFAND5
Most correlated modules
- TCR Early Activation · correlation 0.92
- Pre-mRNA Splicing · correlation 0.89
- Ubiquitin-p53 Regulation · correlation 0.89
- hnRNP Splicing Complex · correlation 0.88
- Stress Epigenetic Silencing · correlation 0.88
- NF-κB Activation · correlation 0.87
- TGF-beta Response · correlation 0.83
- Autophagy Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.