Autophagy Stress Response
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
SQSTM1 (p62, canonical autophagy cargo receptor), FOXO3 (master transcription factor for autophagy and stress survival), TP53INP2-neighbor DNAJB2 (chaperone-assisted selective autophagy), RC3H1/Roquin (mRNA decay, post-transcriptional stress response), TMED7 (ER-Golgi vesicular trafficking), PPP2R2A/PPP4R2 (phosphatases regulating mTOR/autophagy signaling), RHOH (hematopoietic Rho GTPase, lymphocyte signaling), FOXO3+SQSTM1 co-expression points to an autophagy/proteostasis stress program. BRD9 and MLXIP are peripheral. Neighbor M160 also has lysosomal (NEU1) and ubiquitin components consistent with this proteostatic neighborhood.
Genes
AKIRIN1, BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L, PPP2R2A, PPP4R2, RBM22, RC3H1, RHOH, SLC3A2, SNX25, SQSTM1, TAF1D, TIMM10B, TMED7, TMX4
Most correlated modules
- Ubiquitin-p53 Regulation · correlation 0.90
- hnRNP Splicing Complex · correlation 0.89
- Stress Epigenetic Silencing · correlation 0.89
- Chromatin Epigenetic Regulation · correlation 0.88
- Pre-mRNA Splicing · correlation 0.85
- ER Stress Response · correlation 0.84
- RNA Binding/Splicing · correlation 0.84
- mRNA Splicing Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.