SND1 — Staphylococcal nuclease and tudor domain containing 1
SND1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SND1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Antigen Processing Protein processing & ER | ACLY, ATL3, ATR, CANX, DCTN1, DDB1, ERAP1, FOXJ3 +9 more | |
| Hematopoietic progenitor cells | ER Protein Folding Housekeeping | ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2 +13 more | |
| Macrophages | Innate Immune Dampening Innate immunity | DCAF6, ELL2, FGD4, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANP32E, ARHGAP30, CANX, DCTN1, EPRS1, FLII, HK1, JAK3 +9 more |
About the gene
| Synonyms | p100, TDRD11 |
|---|---|
| Chromosome | 7: 127652194-128092609 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Endonuclease, Hydrolase, Nuclease |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5 (By similarity). (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.