Glial Quiescence State
Gene co-expression module in Glial cells
| Category | Development |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
SOX2 is a master transcription factor for neural stem/progenitor cells and is expressed in enteric glial progenitors; CDKN1C (p57/KIP2) is a cyclin-dependent kinase inhibitor associated with cell cycle exit and quiescence; AATK (apoptosis-associated tyrosine kinase) is involved in neuronal/glial differentiation and growth arrest; RGCC (regulator of cell cycle) modulates cell cycle re-entry; SLC38A2 is an amino acid transporter upregulated in quiescent/metabolically active cells; FADS3 is a fatty acid desaturase; RSRP1 is an SR-related protein; PPP1R10 is a phosphatase regulatory subunit. SOX2, CDKN1C, and AATK together suggest a quiescent glial progenitor or growth-arrested state. SRSF5 is an SR splicing factor. The module coherence is strong and connects to M18 (glial progenitor identity) as a neighbor, reinforcing the developmental/progenitor interpretation. This module more specifically captures cell cycle exit/quiescence in a glial progenitor context.
Genes
AATK, CDKN1C, FADS3, PPP1R10, RGCC, RSRP1, SLC38A2, SOX2, SRSF5
Most correlated modules
- Hypoxia mTOR Stress · correlation 0.84
- Anti-proliferative mRNA Decay · correlation 0.70
- Cytoskeletal Glial Homeostasis · correlation 0.66
- Glucocorticoid Stress Recovery · correlation 0.66
- DNA Damage Response · correlation 0.56
- Glial Progenitor Identity · correlation 0.52
- Immediate Early Gene Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.