Glial Vesicle Trafficking
Gene co-expression module in Glial cells
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
BEX3 (brain expressed X-linked 3), ITM2C (integral membrane protein 2C, amyloid precursor-related), and VAMP2 (synaptic vesicle SNARE) are neuroglial membrane/vesicle trafficking genes. PGRMC1 (progesterone receptor membrane component) is expressed in enteric glia and modulates neuroprotection. PLD3 is a lysosomal phospholipase enriched in neurons and glia. FKBP1A is a prolyl isomerase involved in receptor signaling. TUBB encodes beta-tubulin for cytoskeletal structure. CCNI is a cyclin with roles in neuronal survival. The module likely reflects a glial neuronal-support/vesicle trafficking identity program, upregulated in UC remission.
Genes
BEX3, CCNI, FKBP1A, HMGN2, ITM2C, PGRMC1, PLD3, TCEAL7, TUBB, VAMP2
Most correlated modules
- Antioxidant Stress Response · correlation 0.94
- Rho GTPase Signaling · correlation 0.90
- ER Membrane Homeostasis · correlation 0.85
- Oxidative Stress Response · correlation 0.82
- ECM Homeostatic Regulation · correlation 0.82
- Actin Cytoskeletal Organization · correlation 0.82
- ER-Mitochondria Housekeeping · correlation 0.81
- Lysosomal Sphingolipid Metabolism · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.