SCUBA

HMGN2 — High mobility group nucleosomal binding domain 2

HMGN2 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HMGN2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsCell Cycle G1/S
Cell cycle
CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, MND1, MYBL2 +8 moreView in SCUBA
CD8⁺ T cellsMitotic Spindle
Cell cycle
ASF1B, CENPN, DDX39A, DTYMK, GGH, HMGB2, LMNB1, STMN1 +3 moreView in SCUBA
EnterocytesNucleolar RNA-binding
RNA processing & translation
HMGB1, HNRNPA1, HNRNPA2B1, HNRNPA3, HSP90AA1, HSP90AB1, NCL, NPM1 +2 moreView in SCUBA
Gamma-delta T cellsCellular Homeostasis
Housekeeping
ANAPC11, BANF1, CALM3, CBX3, CBX5, COMMD4, DPM2, DUT +21 more
Glial cellsGlial Vesicle Trafficking
Housekeeping
BEX3, CCNI, FKBP1A, ITM2C, PGRMC1, PLD3, TCEAL7, TUBB +1 moreView in SCUBA
Goblet cellsS/G2 Preparation
Cell cycle
DTYMK, EXOSC8, LMNB1, LSM3, LSM5, MIS18A, MIS18BP1, SMC2 +4 moreView in SCUBA
Innate lymphoid cellsMitochondrial OxPhos
Mitochondrial & OxPhos
AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG +21 moreView in SCUBA
MacrophagesMitotic Spindle Assembly
Cell cycle
ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 moreView in SCUBA
Smooth muscle cellsProliferative Biosynthesis
Housekeeping
ARF5, BUB3, CBX5, DCTN3, DUT, IDH2, KRTCAP2, MIF +7 moreView in SCUBA

About the gene

SynonymsHMG17
Chromosome1: 26472440-26476642
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Predicted intracellular proteins
Molecular functionDNA-binding

Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.