Proteostasis Stress Response
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include EIF5 (translation initiation), UBE2D3 and TRIM8 (ubiquitin pathway), SQSTM1 (autophagy receptor/p62), DNAJB6 (chaperone), HNRNPA0 (RNA binding), ZC3HAV1, and NUDT4. The module integrates ubiquitin-proteasome, autophagy (SQSTM1), and translation surveillance — collectively a proteostasis stress response. Uniform expression across glial subsets, increased in UC remission. Neighbor modules share ubiquitin (M30: UBC) and stress-response themes, consistent with a proteostasis network.
Genes
DNAJB6, EIF5, HNRNPA0, NUDT4, RSRC2, SQSTM1, TRIM8, UBE2D3, ZC3HAV1
Most correlated modules
- Glucocorticoid Stress Recovery · correlation 0.91
- Integrated Stress Response · correlation 0.89
- COX-2/NF-κB Inflammation · correlation 0.89
- RNA Translation Processing · correlation 0.89
- Inflammatory Activation Response · correlation 0.88
- Integrated Stress Response · correlation 0.86
- RNA Splicing Processing · correlation 0.86
- DNA Damage Response · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.