COX-2/NF-κB Inflammation
Gene co-expression module in Glial cells
| Category | Inflammation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
All 8 genes are core members. PTGS2 (COX-2, prostaglandin synthesis, canonical inflammatory enzyme), BCL3 (NF-κB co-activator), ARID5A (IL-6 mRNA stabilizer, inflammatory TF), PHLDA1 (stress/NF-κB target), EMP1 (inflammatory membrane protein), LMNA (nuclear lamina remodeling in inflammation), PDLIM3 (cytoskeletal/signaling), ABL2 (tyrosine kinase). Module is upregulated in both UC and CD inflammation (both significant), distinguishing it from neighbors that increase in remission. This is the most pro-inflammatory module in the batch, centered on COX-2/NF-κB signaling.
Genes
ABL2, ARID5A, BCL3, EMP1, LMNA, PDLIM3, PHLDA1, PTGS2
Most correlated modules
- Integrated Stress Response · correlation 0.92
- Proteostasis Stress Response · correlation 0.89
- Integrated Stress Response · correlation 0.86
- RNA Translation Processing · correlation 0.82
- DNA Damage Response · correlation 0.79
- Inflammatory Cytokine Signaling · correlation 0.77
- RNA Splicing Processing · correlation 0.77
- Glucocorticoid Stress Recovery · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.