S100 Glial Activation
Gene co-expression module in Glial cells
| Category | Activation |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
S100A4, S100A6, and S100A10 are calcium-binding S100 family proteins highly expressed in glia and involved in cytoskeletal regulation, cell motility, and glial activation. CDC42EP5 is a Cdc42 effector regulating actin/septin cytoskeleton. CRIP2 is a LIM-domain protein associated with actin and smooth muscle cytoskeleton. TPPP3 promotes tubulin polymerization. EMP3 is a membrane protein expressed in glia. This module captures S100-driven glial cytoskeletal and calcium-signaling state, characteristic of reactive or activated enteric glia. Neighbor context with M4 (also cytoskeletal) supports this interpretation.
Genes
CDC42EP5, CREB5, CRIP2, EMP3, S100A10, S100A4, S100A6, TPPP3
Most correlated modules
- Glial Cytoskeletal Homeostasis · correlation 0.80
- Glutathione Detoxification · correlation 0.76
- TGF-beta ECM Remodeling · correlation 0.74
- Glial Identity Homeostasis · correlation 0.72
- Basement Membrane Adhesion · correlation 0.69
- Glial Myelination Identity · correlation 0.68
- Actin Remodeling Migration · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.