SCUBA

PLP2 — Proteolipid protein 2

PLP2 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PLP2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsMembrane adhesion remodeling
migration & adhesion
ARL6IP5, ATP6V0E1, CAMK1D, CAST, CELF2, DDAH2, EMP3, FLNA +6 moreView in SCUBA
CD4⁺ T cellsCytotoxic effector
Cytotoxicity
ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, KLRG1, LYAR +11 moreView in SCUBA
FibroblastsCaveolae Mechanosensing
Migration & adhesion
CAVIN1, FNBP1, KLHL5, LDLRAD3, MAP3K20, PDLIM3, PHLDB2, PLEKHO1 +6 moreView in SCUBA
Goblet cellsSterol Biosynthesis
Housekeeping
ACAT2, CKLF, COPS9, DHCR24, EBP, FDPS, TXNDC17View in SCUBA
Hematopoietic progenitor cellsMHC-I Antigen Presentation
Myeloid development
ACTB, B2M, CALM2, CAPG, CYBA, EVI2A, EVI2B, FUT7 +10 more
Innate lymphoid cellsNK Homing Circulating
Homing & TEM
ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 moreView in SCUBA
MacrophagesInflammatory Monocyte Activation
Inflammatory
ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 moreView in SCUBA
MonocytesGranulocytic Differentiation
Developmental
CSF3R, GLT1D1, HEBP2, NDUFB9, NRGN, PNPLA2, PXN, SMARCD3 +2 moreView in SCUBA

About the gene

SynonymsA4, A4-LSB, MGC126187
ChromosomeX: 49171898-49175235
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins, Transporters

Function

May play a role in cell differentiation in the intestinal epithelium

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.