TXNDC17 — Thioredoxin domain containing 17
TXNDC17 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TXNDC17's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, BATF, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2 +6 more | View in SCUBA |
| CD8⁺ T cells | Complex I / OXPHOS Mitochondrial & OxPhos | DAD1, GSTO1, GTF3C6, MANF, NDUFA12, NDUFA4, NDUFAB1, NDUFB3 +1 more | View in SCUBA |
| Endothelial | ER Protein Processing Protein processing & ER | AP2S1, ATOX1, C1QBP, CCT3, DBI, ENO1, NHP2, OSTC +5 more | View in SCUBA |
| Fibroblasts | Metabolic Homeostasis Housekeeping | ADH5, ALDH2, ATP2B1, ISCU, NBL1, NLGN4X, PGM1, PKIG +4 more | View in SCUBA |
| Goblet cells | Sterol Biosynthesis Housekeeping | ACAT2, CKLF, COPS9, DHCR24, EBP, FDPS, PLP2 | View in SCUBA |
| Macrophages | ATP Synthase Complex Mitochondrial & OxPhos | ATP5MJ, ATP5MK, ATP5PF, COX7A2, COX7B, GTF2A2, GTF3C6, LSM6 +14 more | View in SCUBA |
About the gene
| Synonyms | MGC14353, TRP14, TXNL5 |
|---|---|
| Chromosome | 17: 6640985-6644541 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.