Chromatin Organization
Gene co-expression module in Goblet cells
| Category | chromatin regulation & transcription |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes HMGB1, HMGB3, HMGN1 are all HMG (High Mobility Group) chromatin-architectural proteins. CBX3 (HP1γ) regulates heterochromatin. PTMA is involved in chromatin remodeling and nucleosome assembly. STMN1 co-regulates with chromatin dynamics. HNRNPA2B1 participates in chromatin-associated RNA processing. The module is tightly coherent and uniformly expressed, consistent with constitutive chromatin regulation suppressed during inflammation.
Genes
CBX3, HMGB1, HMGB3, HMGN1, HNRNPA2B1, PTMA, STMN1, TPRKB
Most correlated modules
- Chromatin RNA Regulation · correlation 0.88
- CCT Chaperonin Complex · correlation 0.84
- S/G2 Preparation · correlation 0.82
- hnRNP RNA Processing · correlation 0.82
- Chromatin Remodeling · correlation 0.77
- Mitochondrial Homeostasis · correlation 0.74
- Spliceosome Assembly · correlation 0.73
- RNA Decay Processing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.