MAT2B — Methionine adenosyltransferase 2B
MAT2B belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAT2B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAPK feedback signaling TCR/AP1/NFKb pathway | BACH1, DUSP16, DUSP4, E2F3, EPSTI1, PELI1, PIM2, SEC14L1 +2 more | View in SCUBA |
| Gamma-delta T cells | T Cell Survival T cell maturation | CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5 +13 more | |
| Goblet cells | Ion Transport Homeostasis Housekeeping | APP, ATP1A1, CAPRIN1, CSDE1, EEF2, SLC12A2, TMEM123, VPS35 | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E +17 more | View in SCUBA |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Biogenesis & Folding Housekeeping | ADH5, CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MFSD10 +6 more |
About the gene
| Synonyms | MATIIbeta, SDR23E1 |
|---|---|
| Chromosome | 5: 163503114-163519558 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Biological process | One-carbon metabolism |
Function
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.