Mitochondrial Biogenesis
Gene co-expression module in Goblet cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
PRELID1 (mitochondrial phosphatidic acid transporter), SLC25A39 (mitochondrial solute carrier family 25), MRPL17, MRPL20, MRPL41 (mitochondrial ribosomal proteins of the large subunit) define a clear mitochondrial program. EIF5A supports mitochondrial translation elongation and is known to localize to mitochondria. PFN1, CALM1, and ARPC5L represent cytoskeletal/signaling components. SRM (spermidine synthase) supports polyamine metabolism linked to mitochondrial function. SNU13, LSM7, SNRNP25 are minor spliceosomal members. The module decreases with CD inflammation (-0.088), consistent with downregulation of mitochondrial housekeeping in inflamed epithelium. The dominant program is mitochondrial biogenesis/function.
Genes
ARPC5L, CALM1, EIF5A, LSM7, MRPL17, MRPL20, MRPL41, PFN1, PRELID1, SLC25A39, SNRNP25, SNU13, SRM
Most correlated modules
- Proteostasis Housekeeping · correlation 0.79
- Mitochondrial OxPhos · correlation 0.77
- Spliceosome Assembly · correlation 0.75
- SR Splicing Factors · correlation 0.71
- Mitochondrial Chaperone · correlation 0.70
- Mitochondrial Biogenesis · correlation 0.70
- Pyroptosis Stress Response · correlation 0.70
- Ubiquitin-Proteasome Degradation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.