MRPL12 — Mitochondrial ribosomal protein L12
MRPL12 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MRPL12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos | ATIC, ATP5MC1, C1QBP, CCT7, DCTPP1, EBNA1BP2, EEF1E1, EIF5A +13 more | View in SCUBA |
| CD4⁺ T cells | Nucleotide biosynthesis Housekeeping | CCT7, COPRS, DCTPP1, MRPL4, NHP2, NME1, PPA1, PRDX4 +6 more | View in SCUBA |
| Endothelial | Redox Stress Response Stress | APEX1, ATP5F1E, ATP5MC1, CDC42EP5, EIF4EBP1, EPS8L1, MAGED1, MCFD2 +7 more | View in SCUBA |
| Goblet cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARL6IP4, ATP5F1D, CHCHD10, CISD3, CYBA, GADD45GIP1, METTL26, MIF +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Nucleotide Metabolism Housekeeping | DCTPP1, DNPH1, EIF4EBP1, FKBP4, GCSH, METTL26, NHP2, NME4 +2 more | |
| Macrophages | Complex I / NADH Dehydrogenase Mitochondrial & OxPhos | AHCY, ANP32A, ANTKMT, APEX1, ARL2, ATIC, ATP5F1A, ATP5ME +31 more | View in SCUBA |
About the gene
| Synonyms | MRPL7, MRPL7/L12, RPML12 |
|---|---|
| Chromosome | 17: 81703367-81707517 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, Ribosomal protein |
Function
As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.