TAX1BP1 — Tax1 binding protein 1
TAX1BP1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TAX1BP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated effector Tcell Immune regulation | APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST +4 more | View in SCUBA |
| Goblet cells | Ubiquitin Protein Homeostasis Housekeeping | ARPC2, BZW1, CMTM6, CSNK1A1, DAP, EMP2, GNAI3, KIF5B +6 more | View in SCUBA |
| Innate lymphoid cells | DNA Damage Response Stress | ANP32E, CCT6A, CLTB, FGFR1OP2, GNL3, HNRNPF, JPT1, MRPS6 +7 more | View in SCUBA |
| Macrophages | RNA Processing Regulation Housekeeping | ACBD3, AQR, ARCN1, BFAR, BNIP3L, CCNI, CCNK, DIS3 +15 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1 +11 more |
About the gene
| Synonyms | CALCOCO3, TXBP151 |
|---|---|
| Chromosome | 7: 27739331-27844564 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Apoptosis, Autophagy, Host-virus interaction, Immunity, Innate immunity |
Function
Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation. Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates. Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN- beta production. Also recruits A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways. Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS- mediated apoptosis signaling. As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis. Upon NBR1 recruitment to the SQSTM1- ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation. Mediates the autophagic degradation of other substrates including TICAM1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.