KIF20B — Kinesin family member 20B

KIF20B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

KIF20B's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR Activation Signaling TCR/AP1/NFKb pathway	AKNA, ATP6V1A, BCL2L11, LAX1, NAA50, NEDD9, NPC1, PRKAR1A +6 more	View in SCUBA
Endothelial	Mitotic Spindle Cell cycle	ASPM, CCNB1, CDK1, CENPE, CENPF, CKAP2, KNSTRN, LMNB1 +14 more	View in SCUBA
Goblet cells	Mitotic Proliferation Cell cycle	BIRC5, CCNA2, MKI67, PBK, RACGAP1, TOP2A, TPX2	View in SCUBA

About the gene

Synonyms	CT90, KRMP1, MPHOSPH1, MPP1
Chromosome	10: 89701590-89774939
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Motor protein
Biological process	Cell cycle, Cell division, Mitosis

Function

Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.