Hypoxia Metabolic Stress
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
ANKRD37 is a well-validated HIF1α target gene induced by hypoxia. KLF2 is upregulated under shear/metabolic stress. IRS2 mediates insulin/IGF survival signaling under nutrient stress. FBXO32 (atrogin-1/MAFbx) is an E3 ubiquitin ligase activated by metabolic/oxidative stress and fasting. SKIL (SnoN) negatively regulates TGF-β signaling. TENT5A is a cytoplasmic poly-A polymerase involved in ER stress responses. LRRFIP1 is an innate immune/stress sensor. Upregulated in UC inflammation with partial UC-specificity. The combination of HIF target (ANKRD37), metabolic stress TF (KLF2), and stress ubiquitin ligase (FBXO32) with TGF-β modulation (SKIL) supports a hypoxia/metabolic stress program.
Genes
ADGRE5, ANKRD37, ARL4A, FBXO32, IRS2, KLF2, LRRFIP1, SKIL, TENT5A
Most correlated modules
- Stress Survival Response · correlation 0.88
- EGF-Driven Wound Repair · correlation 0.81
- Actin Cytoskeletal Remodeling · correlation 0.78
- Basement Membrane Remodeling · correlation 0.69
- Mucin Glycosylation Remodeling · correlation 0.67
- Golgi-Exocytosis Machinery · correlation 0.66
- ERAD ER Homeostasis · correlation 0.65
- S100 Calcium Signaling · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.