IMPA2 — Inositol monophosphatase 2
IMPA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IMPA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | hnRNP RNA Processing RNA processing & translation | CCT2, HNRNPAB, HNRNPD, HNRNPR, ILF3, SERBP1, SET, TAF15 | View in SCUBA |
| Macrophages | Inflammasome Oxidative Stress Inflammatory | ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more | View in SCUBA |
About the gene
| Chromosome | 18: 11981025-12030877 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Phosphatase that can use myo-inositol monophosphates, myo- inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1- phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro. It is likely that IMPA2 has an as yet unidentified in vivo substrate(s). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.