Stress Survival Response
Gene co-expression module in Goblet cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Core-coherence module with hub genes KLF6 (wound/stress TF), MCL1 (anti-apoptotic survival), VMP1 and SQSTM1 (autophagy), ERRFI1 (EGFR negative feedback/stress), EPHA2 (epithelial repair receptor), TRIB1 (stress-kinase pseudokinase), LMNA (nuclear integrity under stress), UBC (ubiquitin). Together these define a stress-survival program: anti-apoptosis (MCL1), autophagy flux (VMP1/SQSTM1), stress TF activation (KLF6), and ubiquitin-proteasome engagement (UBC). Upregulated in IBD inflammation, partially maintained in CD remission.
Genes
EPHA2, ERRFI1, EZR, KLF6, LDLR, LMNA, MCL1, NEDD9, SQSTM1, TRIB1, UBC, VMP1
Most correlated modules
- EGF-Driven Wound Repair · correlation 0.90
- Hypoxia Metabolic Stress · correlation 0.88
- Basement Membrane Remodeling · correlation 0.74
- NF-κB Stress Response · correlation 0.72
- Stress Chromatin Remodeling · correlation 0.69
- Actin Cytoskeletal Remodeling · correlation 0.68
- NF-kB Inflammatory Signaling · correlation 0.65
- Goblet Cell Differentiation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.