CD69 — CD69 molecule
CD69 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD69's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | AP-1 Immediate Early BCR/AP1/NFKb pathway | BTG2, CD83, DUSP1, EIF1, FOS, FOSB, JUN, JUNB +7 more | View in SCUBA |
| CD4⁺ T cells | Immediate Early AP-1 TCR/AP1/NFKb pathway | BTG2, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2, IER5 +6 more | View in SCUBA |
| CD8⁺ T cells | AP-1 Early Activation TCR Signaling | BTG2, EGR1, FOS, FOSB, IER2, JUNB, LEPROTL1, LITAF +5 more | View in SCUBA |
| Gamma-delta T cells | TCR Early Activation TCR Signaling | BTG1, BTG2, CIRBP, CXCR4, DUSP1, EIF1, ETV3, FOS +15 more | |
| Goblet cells | NF-kB Inflammatory Signaling chromatin regulation & transcription | CXCR4, DDX21, DUSP2, FOSL2, IRF1, NFKB2, REL, RGCC +5 more | View in SCUBA |
| Innate lymphoid cells | Cytokine-driven Activation activation | BIRC3, CALR, DUSP5, GADD45G, ISG15, NCOA7, PPIF, RUNX3 +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Activation T cell maturation | BTG2, CCNL1, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1, FOSB +7 more |
About the gene
| Synonyms | CLEC2C |
|---|---|
| Chromosome | 12: 9752486-9760901 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types. Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells. Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (By similarity). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T- lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT. Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion. In eosinophils, induces IL-10 production through the ERK1/2 pathway (By similarity). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.