SPCS3 — Signal peptidase complex subunit 3
SPCS3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPCS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Pre-mRNA Splicing RNA processing & translation | BRD2, EIF3A, FUS, HNRNPU, HSPA9, NCL, PNN, RBM25 +5 more | View in SCUBA |
| Endothelial | Hypoxia Response Stress | C1orf122, CRELD2, CSTB, EFHD2, FKBP1A, HIF1A, LAPTM4B, NECTIN2 +3 more | View in SCUBA |
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2 +12 more | |
| Goblet cells | ER Protein Translocation Protein processing & ER | DNAJC3, LMAN1, PDIA6, RPN2, SPCS2, SSR1, TMED10, TMED2 | View in SCUBA |
| Innate lymphoid cells | Golgi RNA Processing RNA processing & translation | ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC +11 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, EIF4G2, GARS1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Transcriptional Identity T cell maturation | AAK1, ANKRD36B, ATG16L2, BCL11B, EMB, ETS1, GOLGA8B, HNRNPUL2 +8 more |
About the gene
| Synonyms | FLJ22649, PRO3567, SPC22/23, SPC3, YLR066W |
|---|---|
| Chromosome | 4: 176319966-176332245 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Metabolic proteins, Predicted intracellular proteins |
Function
Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.