PMAIP1 — Phorbol-12-myristate-13-acetate-induced protein 1

PMAIP1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PMAIP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Integrated Stress Response Stress	AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PHF1 +4 more	View in SCUBA
CD4⁺ T cells	TNF/NF-kB activation TCR/AP1/NFKb pathway	BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, RBBP8 +6 more	View in SCUBA
Endothelial	NF-κB Activation Inflammation	C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBIA, NFKBID, PTGS2 +5 more	View in SCUBA
Fibroblasts	BMP-ID Stress Response Stress	BHLHE40, CCDC184, CFAP20, FOXC2, GADD45G, GDF15, GDNF, HAS1 +9 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PHLDA1 +5 more
Goblet cells	Stress Chromatin Remodeling chromatin regulation & transcription	ETS2, GADD45A, KDM6B, SDC4, SOX9, YBX3, ZBTB7A, ZFAND5 +1 more	View in SCUBA
Innate lymphoid cells	mTOR Stress Response Stress	CEBPB, DDIT3, DDIT4, GLS, ID1, IFRD1, INTS6, JMJD6 +9 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Stress Response Stress	BTG2, FOSB, MYLIP, PLK3, PPP1R10, PPP1R15B, RGS2, VMP1 +1 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, IER5, MARCKSL1, NFKBIA, NFKBIZ, PPP1R15A, PPP1R15B +1 more	View in SCUBA

About the gene

Synonyms	APR, NOXA
Chromosome	18: 59899996-59904305
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Apoptosis

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.