SDC4 — Syndecan 4
SDC4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SDC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1 +6 more | View in SCUBA |
| Endothelial | Endothelial Chemokine Response Chemotaxis | BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3 +14 more | View in SCUBA |
| Goblet cells | Stress Chromatin Remodeling chromatin regulation & transcription | ETS2, GADD45A, KDM6B, PMAIP1, SOX9, YBX3, ZBTB7A, ZFAND5 +1 more | View in SCUBA |
| Innate lymphoid cells | ILC Survival Residency Gut residency | ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more | View in SCUBA |
| Lymphatic endothelial | AhR mRNA Regulation RNA processing & translation | CYP1B1, DHRS3, ESAM, HNRNPDL, HNRNPH1, LIF, TIPARP, TPBG +3 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
| Monocytes | Hypoxia Response Tissue adaptation | ANPEP, ELL2, GNA15, HIF1A, NDRG1, RUNX1, SLC7A5, SPAG9 +2 more | View in SCUBA |
About the gene
| Synonyms | amphiglycan, ryudocan, SYND4 |
|---|---|
| Chromosome | 20: 45325288-45348424 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted membrane proteins, Predicted secreted proteins, Transporters |
Function
Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.