VAPA — VAMP associated protein A
VAPA belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VAPA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actin Vesicle Trafficking Cytoskeletal | ABRACL, ACTR3, ADRM1, ANKRD9, C3orf14, CISD2, CLIC1, EIF2S1 +10 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeleton Cytoskeletal | ACTB, CAPZA2, CFL1, CMTM6, COX8A, KIF5B, MORF4L2, NDUFS5 +6 more | View in SCUBA |
| Glial cells | ER Membrane Homeostasis Neroprotection | GNAI2, KHDRBS3, LITAF, RTN4, SARAF, SBDS, SH3BGRL, SNCA +1 more | View in SCUBA |
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2 +11 more | View in SCUBA |
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATAD1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3 +17 more | View in SCUBA |
| Smooth muscle cells | Actin Dynamics Housekeeping Housekeeping | C12orf75, CAPZA2, CFL1, ELN, ENY2, PPIA, PRDX1, PSMB1 +3 more | View in SCUBA |
About the gene
| Synonyms | hVAP-33, VAP-A |
|---|---|
| Chromosome | 18: 9914016-9960021 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction |
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.