TMEM165 — Transmembrane protein 165
TMEM165 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMEM165's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NF-κB Stress Response Inflammatory | EGR3, NAMPT, NCOA7, NFIL3, PHLDA1, PHLDA2, SAT1, SLC20A1 +3 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Repair DNA/chromatin regulation | ANKRD10, ASF1A, DDX18, DNAJC17, ENPP5, KLRC4, KLRD1, NARS1 +15 more | |
| Macrophages | Endolysosomal Trafficking Lysosomal & pahgocytosis | ACVR1, ATAD1, ATP6V1C1, CSNK2A1, CTNNB1, DDX6, EMILIN2, GNAI3 +17 more | View in SCUBA |
| Pericytes | NF-κB Inflammatory Activation Inflammatory | CTSS, EFHD2, HIF1A, IL32, LAP3, OSMR, TAPBP | View in SCUBA |
| Smooth muscle cells | XBP1 UPR Response Protein processing & ER | ADAMTS10, AKAP13, ATP1A1, BATF3, BNIP3L, CHRD, DLC1, HERPUD1 +5 more | View in SCUBA |
About the gene
| Synonyms | GDT1, SLC64A1, TMPT27, TPARL |
|---|---|
| Chromosome | 4: 55395957-55453397 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Antiport, Transport |
Function
Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.